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From Defiance 2050 Wiki
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Defiance is both a game by Trion Worlds and a television series from Syfy both set in the Defiance universe.

The television series ran for three seasons for three seasons from April 15, 2013 to its cancellation on October 16, 2015. The game was launched on April 2, 2013 and is still running at the time of this writing. These two sources establish the existing canon for the Defiance universe in which Defiance 2050 is set, though Trion Worlds the revamp of many systems in the new game resulted in some degree of retcon.